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Nevertheless, the chronic treatment with L-dopa See more information
has several significant limitations and side-effects which include motor fluctuations, dyskinesias, and neuropsychiatric problems due to the increased dopaminergic activity of all five dopaminergic pathways in the brain, as well as up and down regulations of dopaminergic receptors ().
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Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies".
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Anti-amyloidogenic effects of antioxidants: Implications for the prevention and therapeutics of Alzheimer's disease.
Unfortunately, most L-dopa is broken down in the body before it ever reaches the brain unless special chemicals are used with levodopa.
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Since dyskinesia was much more common in the levodopa group (45 percent) than in the ropinirole group (20 percent), a lower rate of supplementation in the levodopa group may have resulted.
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REXULTI was specifically designed to have similar activity at 2 of these receptors: serotonin and dopamine.
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